Preclinical evaluations of the effects of a foot-care formula on restoration and recovery of skin barrier integrity.

Author: Kátia Nunes da Silva; Carlos Eduardo Ramos Dalseno; Gustavo Henrique da Silva; Gabriela da Silva Leite; Ana Lucia Tabarini Alves Pinheiro; Gustavo Facchini; Samara Eberlin; Barbara de Freitas Carli.  

Published at: January 01, 2024

https://kosmoscience.com/pdf/preclinical-evaluations-of-the-effects-of-a-foot-care-formula-on-restoration-and-recovery-of-skin-barrier-integrity.pdf

The skin barrier relies on key proteins like filaggrin, involucrin, loricrin and keratins for stratum corneum formation, improve cell stability and create a protective shield that ensures skin resilience against external threats. Dysfunction in these proteins can compromise the skin barrier, leading to various dermatological issues The purpose for this study was to evaluate the preclinical effects of a foot-care product 202106059 (FC202106059) on the production of biological markers involved in skin barrier integrity and epidermal repair through immunofluorescence analysis in skin explants.