Clinical Assessment of Anti-Aging Benefits of a Facial Skincare Formulation: a biomarker-centered approach to antioxidative defense.

Author: Ana Lucia Tabarini Alves Pinheiro; Silas Arandas Monteiro Silva; Letícia Gomes; Carla Monserrat Grecco Lopes; Barbara de Freitas Carli; Vania Renata Gonçalves; Gustavo Facchini; Samara Eberlin.

Published at: January 01, 2024

https://kosmoscience.com/pdf/clinical-assessment-of-anti-aging-benefits-of-a-facial-skincare-formulation-a-biomarker-centered-approach-to-antioxidative-defense.pdf

Skin homeostasis requires a balance between free radical production and natural antioxidant defense. MMPs Collagen breakdown Francisqueti-Ferron FV, Ferron AJT, Garcia JL, et al. Int J Mol Sci. 2019;20(13):3208. • Oxidative process is dynamic and rapid restoration mechanisms are necessary to maintain the structural integrity of the skin. • NRF2 (Nuclear Factor Erythroid 2-related factor 2) is considered the key regulator antioxidant response, being responsible for induce the expression of genes encoding proteins and antioxidant enzymes, playing an important mechanism for cell protection and survival. • Among NRF2 target genes are superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx).