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Effects of antioxidants in the protection of infrared radiation-induced matrix metalloproteinase-1 in human dermal fibroblast


Effects of antioxidants in the protection of infrared radiation-induced matrix metalloproteinase-1 in human dermal fibroblast
Postado por: Samara Eberlin em 09 de Junho de 2016

Journal of the American Academy of Dermatology, 70(5) Supplement 1, AB155, 2014.

DOI: http://dx.doi.org/10.1016/j.jaad.2014.01.644

Physiological doses of infrared A radiation (IR-A) lead to a disturbance of the dermal extracellular matrix by upregulation of matrix metalloproteinase-1 (MMP1) and decrease antioxidant enzyme activity. As such, the infrared induced cytotoxicity, DNA damage and oxidative stress. Even though no specific chemical or physical filters direct against IRA are available, there is an alternative that can provide a sunscreen more broadly and favoring protection against photodamage, using antioxidant ingredients. In this study, we evaluated the in vitro effects of two formulations containing the antioxidant ingredients FThe and FCar in the prevention of IR-A-induced damage in human dermal fibroblasts (HDF) through MMP-1 production. Our results demonstrated that irradiation with infrared A resulted in a significant up regulation of MMP-1 production 1.7-fold in relation to non-irradiated group. FCar produced a significant reduction in the release of MMP-1 by human fibroblast in relation to IRA group. In more pronounced, FThe promoted reductions up to 1.35-fold in the levels of MMP-1 when compared to IRA group. The formulations containing FCar and FThe are suitable for protection of IRA-induced MMP-1 upregulation in vitro in human dermal fibroblast cell culture. These effects can be attributed, at least in part, for the known antioxidant activity of these compounds, although the precise mechanisms remain to be clarified.